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Cat. No. | Product Name | Target | Signaling Pathways |
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T78259 |
Anti-Mouse CD8 beta Antibody (53-5.8)
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Anti-Mouse CD8 beta Antibody是一种源自大鼠的IgG1类免疫抑制性抗体,专门针对小鼠的CD8 beta分子。 | |||
T40132 |
Insulin β Chain Peptide (15-23)
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Insulin β Chain Peptide (15-23), also referred to as INS, is an insulin-derived peptide that is specifically recognized by islet-associated T cells. The tetramer of Insulin β Chain Peptide (15-23) effectively stained the INS-reactive CTL clone G9C8; however, neither this tetramer nor the negative control tetramer (TUM) exhibited staining on the splenic CD8+ T cells obtained from NOD or 8.3-TCRαβ transgenic NOD mice. | |||
T83779 |
EP4 Antagonist 14
Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14 |
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EP4 antagonist 14是一种前列腺素E2(PGE2)受体亚型EP4的拮抗剂,其在使用表达人源受体的HEK293细胞的报告基因测定中的IC50值为1.1 nM。它还能抑制PGE2诱导的同种细胞中的β-阿雷斯汀招募(IC50 = 0.9 nM)。EP4 antagonist 14(10 µM)能减少RAW 264.7巨噬细胞中PGE2诱导的mRNA表达,这些mRNA编码Il-4、巨噬细胞甘露糖受体1(Mrc1)、几丁质酶样蛋白3(Chil3)、趋化因子(C-X-C)基序配体1(Cxcl1)、表达在髓样细胞上的触发受体2(Trem2)和精氨酸酶-1(Arg1)。在体内,EP4 antagonist 14(每天30 mg/kg),结合抗PD-1抗体,能够在CT26小鼠结肠癌模型中抑制肿瘤生长并增加CD8+ T细胞对肿瘤的浸润。 |
Cat. No. | Product Name | Species | Expression System |
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TMPY-04925 |
CD8 beta Protein, Human, Recombinant, Biotinylated
LY3,LYT3,CD8b molecule,P37,LEU2,CD |
Human | HEK293 Cells |
CD8 beta Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 17.6 kDa and the accession number is P10966-1. | |||
TMPY-06256 |
CD8 beta Protein, Cynomolgus, Recombinant (hFc)
CD8 β,CD8b mole... |
Cynomolgus | HEK293 Cells |
CD8 beta Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.88 kDa and the accession number is XP_005575417.1. | |||
TMPJ-00092 |
CD8 beta Protein, Human, Recombinant (His)
T-Cell Surface Glycoprotein CD8 Beta Chain... |
Human | HEK293 Cells |
T-Cell Surface Glycoprotein CD8β Chain (CD8 Antigen) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 Antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha a... | |||
TMPY-02925 |
CD8 beta Protein, Human, Recombinant
LEU2,P37,CD8b molecule,LYT3,CD |
Human | HEK293 Cells |
CD8 beta Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 17.6 kDa and the accession number is P10966-1. | |||
TMPY-05350 |
CD8 alpha Protein, Cynomolgus, Recombinant (hFc)
CD8 α,CD8a molecule |
Cynomolgus | HEK293 Cells |
CD8 alpha Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is XP_005575419.1. | |||
TMPY-02703 |
CD8 beta Protein, Human, Recombinant (hFc)
LYT3,CD8 β,CD8b... |
Human | HEK293 Cells |
CD8 beta Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44 kDa and the accession number is P10966-1. | |||
TMPY-05364 |
CD8 alpha Protein, Human, Recombinant (hFc)
Leu-2,p32 186910,p32,CD8 α,CD... |
Human | HEK293 Cells |
CD8 alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.3 kDa and the accession number is P01732-1. | |||
TMPY-05134 |
CD8 alpha Protein, Mouse, Recombinant (His), Biotinylated
Lyt-2,Ly-35,Ly-B,CD8a molecule,Ly-2,BB1543... |
Mouse | HEK293 Cells |
CD8 alpha Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.3 kDa and the accession number is P01731. | |||
TMPY-06274 |
CD8 alpha Protein, Human, Recombinant (His)
CD8 alpha,Leu-2,p32 186910,CD... |
Human | CHO Cells |
CD8 alpha Protein, Human, Recombinant (His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is P01732-1. | |||
TMPY-05046 |
CD8 alpha Protein, Mouse, Recombinant (hFc)
BB154331,Ly-B,Ly-2,CD8 α,Lyt-2,Ly-35,C... |
Mouse | HEK293 Cells |
CD8 alpha Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.6 kDa and the accession number is P01731. | |||
TMPY-02165 |
CD8 alpha Protein, Ferret, Recombinant (His)
CD8a molecule,CD8 α |
Ferret | HEK293 Cells |
CD8 alpha Protein, Ferret, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.5 kDa and the accession number is I6LI23. | |||
TMPY-06275 |
CD8 alpha Protein, Human, Recombinant (His), Biotinylated
MAL,CD8,CD8a molecule,Le... |
Human | CHO Cells |
CD8 alpha Protein, Human, Recombinant (His), Biotinylated is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is P01732-1. | |||
TMPY-03913 |
CD8 alpha Protein, Rat, Recombinant (hFc)
CD8 α,CD8a molecule |
Rat | HEK293 Cells |
CD8 alpha Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is P07725. | |||
TMPY-01314 |
CD8 alpha Protein, Mouse, Recombinant (His)
Ly-35,CD8a molecule,BB154331,Ly-2,Ly-B, |
Mouse | HEK293 Cells |
CD8 alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.3 kDa and the accession number is P01731. | |||
TMPY-06933 |
CD8 alpha Protein, Human, Recombinant (His & Avi), Biotinylated
p32 186910,MAL,CD8,Leu2,CD |
Human | HEK293 Cells |
CD8 alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 20.87 kDa and the accession number is NP_001759.3. | |||
TMPK-00123 |
CD8 alpha Protein, Human, Recombinant (aa 22-182, His & Avi), Biotinylated
Leu2,CD8 α/CD8A,MAL,Lyt-... |
Human | HEK293 Cells |
CD8 alpha enhances the responses of antigen-specific CTL activated through TCR through binding MHC class I, favoring lipid raft partitioning of TCR, and inducing intracellular signaling. CD8 alpha is also found on dendritic cells and rat macrophages, but whether CD8 alpha enhances responses of a partner receptor, like TCR, to activate these cells is not known. |